MOUSE MODELS: From Genetics to Applications Registration

21-23 May 2018, Yonsei University, Seoul

This course is organised in collaboration with Prof. Han-Woong Lee who has run several editions of a similar course in the past few years, and supported by Yonsei Laboratory Animal Research Centre.

MOUSE MODELS: From Genetics to Applications Registration

21-23 May 2018, Yonsei University, Seoul

The mouse (Mus musculus) is the foremost mammalian model for studying human disease and represents up to 80% of all animals used for research purposes in laboratories.

The ability to model human disease in the mouse makes it an extremely valuable experimental system. The mouse is used in a wide variety of studies including drug toxicity, microbiology, radiobiology, cancer research, behavior research, nutrition, and genetic studies.

The mouse is small, which means it’s easy to house and inexpensive. It can reproduce as often as every 3 weeks with a generation time of around 10 weeks, meaning several generations can be observed at once. It has a short lifespan (one mouse year equals about 30 human years) which means scientists can easily measure the effects of ageing.

An enormous amount of knowledge has been gathered in over 100 years about mouse physiology, anatomy, and genetics revealing many similarities to humans.

The 3,500 million base pair and 23,000 protein-coding genes sequence of the mouse genome was published in December 2002. Genetically the human and the mouse are very similar, with many of disease-related genes nearly identical.

The mouse genome is manipulated routinely nowadays using genetic engineering tools including but not limited to the game changing the latest CRISPR technology, providing a powerful tool for modelling specific diseases. Like humans, mice naturally develop diseases that affect their immune, endocrine, nervous, cardiovascular and skeletal systems including cancer and diabetes.

These similarities make mouse genetic research particularly useful for the study of many human diseases.

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In this hands-on practical course you will learn:

  • general advantages and requirements when establishing and working with mouse models
  • The latest genome engineering tool CRISPR
  • How to collect embryos at various stages for further manipulation
  • How to microinject embryos
  • How to perform IVF and the associated procedures from collecting sperm, eggs, to performing superulation and embryo transfer
  • General procedures in the animal facility
  • How to design troubleshoot your CRISPR experiment in our CRISPR Clinics

IMPORTANT: Bring your laptop as some of the sessions will need it.

 

 

 

INSTRUCTORS

Professor Han-Woong Lee, Yonsei University

Professor Takehito Kaneko, Iwate University

Professor In-Jeoung Baek, University of Ulsan College of Medicine

Professor Young Hoon Sung, Asan Medical Center, University of Ulsan College of Medicine

Dr Ben Davies, University of Oxford

Dr Thorsten Boroviak, University of Cambridge

Dr Jaehoon Lee, Yonsei University

Dr Jae-Il Roh, Yonsei University

Ms Na-Yeong Ha,  Yonsei Labolatory Animal Research Center

Ms Mi-Yeon Park, Yonsei University

Ms Sun-Ha Park, Yonsei University

 

more about the team

 

Watch one of our previous course video:

 

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